The CADASIL Timeline, also known as the natural history of CADASIL.

Natural history of the main clinical manifestations of CADASIL. The exact age of onset or presentation of MRI abnormalities is uncertain (dotted line). However, T2 white matter abnormalities progressively increase and become constant at around 35 years of age.

From Chabriat H et al. Lancet Neurol. 2009 Jul;8(7):643-53. Review.